Assay Detail
Functional
CHEMBL1212352
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Antiviral activity against HCV 1a infected in human HB-1 cells assessed as inhibition of viral RNA replication after 24 hrs
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | HB-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.28 | 5.28 |
| EC90 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374528 | — | — | 1 | 5.28 |
| CHEMBL223482 | — | — | 1 | - |
| CHEMBL1210986 | — | — | 1 | - |
| CHEMBL1210987 | — | — | 1 | - |
| CHEMBL1210988 | — | — | 1 | - |
| CHEMBL1210989 | — | — | 1 | - |
| CHEMBL1210990 | — | — | 1 | - |
| CHEMBL1210991 | — | — | 1 | - |
| CHEMBL484963 | — | — | 1 | - |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374528 | — | EC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL223482 | — | EC90 | = | 4.6 | uM | - |
| CHEMBL1210986 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1210987 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1210988 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1210989 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1210990 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1210991 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL484963 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL888 | GEMCITABINE | EC50 | < | 1000.0 | nM | - |