Assay Detail
Binding
CHEMBL1212367
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Inhibition of HCV NS5B polymerase L419M mutant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.45 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561360 | — | — | 1 | 6.37 |
| CHEMBL1210273 | — | — | 1 | 5.35 |
| CHEMBL1210272 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561360 | — | Kd | = | 427.0 | nM | 6.37 |
| CHEMBL1210273 | — | Kd | = | 4480.0 | nM | 5.35 |
| CHEMBL1210272 | — | Kd | = | 23090.0 | nM | 4.64 |