Assay Detail
Binding
CHEMBL1212431
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive allosteric modulator activity at human alpha7 nAChR expressed in rat GH4C1 assessed as calcium mobilization by FLIPR assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.62 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1210516 | — | — | 1 | 8.70 |
| CHEMBL1210515 | — | — | 1 | 8.70 |
| CHEMBL1210517 | — | — | 1 | 8.50 |
| CHEMBL1210576 | — | — | 1 | 8.20 |
| CHEMBL1210577 | — | — | 1 | 8.10 |
| CHEMBL1210579 | — | — | 1 | 8.00 |
| CHEMBL1210578 | — | — | 1 | 8.00 |
| CHEMBL1210518 | — | — | 1 | 8.00 |
| CHEMBL1210643 | — | — | 1 | 7.60 |
| CHEMBL1210642 | — | — | 1 | 7.60 |
| CHEMBL1210641 | — | — | 1 | 7.60 |
| CHEMBL1210640 | — | — | 1 | 7.50 |
| CHEMBL257591 | — | — | 1 | 6.80 |
| CHEMBL1210703 | — | — | 1 | 6.80 |
| CHEMBL1210702 | — | — | 1 | 5.90 |
| CHEMBL1210458 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1210516 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL1210515 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL1210517 | — | EC50 | = | 3.162 | nM | 8.50 |
| CHEMBL1210576 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL1210577 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL1210579 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1210578 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1210518 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1210643 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL1210642 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL1210641 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL1210640 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL257591 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL1210703 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL1210702 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL1210458 | — | EC50 | = | 1258.93 | nM | 5.90 |