Assay Detail
Binding
CHEMBL1216774
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Activity at Escherichia coli DH10B beta-lactamase KPC-2 by diode array spectrophotometry
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli str. K-12 substr. DH10B |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kcat | 4 | - | - |
| Ki | 4 | 4.94 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480517 | NITROCEFIN | -1.0 | 2 | 5.30 |
| CHEMBL702 | PIPERACILLIN | 4.0 | 2 | 4.80 |
| CHEMBL148 | IMIPENEM ANHYDROUS | 4.0 | 2 | 4.72 |
| CHEMBL1730 | CEFOTAXIME | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480517 | NITROCEFIN | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL702 | PIPERACILLIN | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL148 | IMIPENEM ANHYDROUS | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL480517 | NITROCEFIN | Kcat | = | 30.0 | /s | - |
| CHEMBL148 | IMIPENEM ANHYDROUS | Kcat | = | 19.0 | /s | - |
| CHEMBL1730 | CEFOTAXIME | Kcat | = | 78.0 | /s | - |
| CHEMBL702 | PIPERACILLIN | Kcat | = | 17.0 | /s | - |
| CHEMBL1730 | CEFOTAXIME | Ki | = | 120000.0 | nM | - |