Assay Detail
Binding
CHEMBL1216943
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p110delta
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.98 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1213118 | — | — | 1 | 9.30 |
| CHEMBL1213084 | — | — | 1 | 9.15 |
| CHEMBL1213117 | — | — | 1 | 9.00 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 8.52 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 8.34 |
| CHEMBL1213116 | — | — | 1 | 8.15 |
| CHEMBL1213085 | — | — | 1 | 8.05 |
| CHEMBL1213120 | — | — | 1 | 7.68 |
| CHEMBL1213169 | — | — | 1 | 7.47 |
| CHEMBL1213119 | — | — | 1 | 7.40 |
| CHEMBL1213168 | — | — | 1 | 7.05 |
| CHEMBL1213082 | — | — | 1 | 6.89 |
| CHEMBL1213083 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1213118 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1213084 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1213117 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL1213116 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1213085 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1213120 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1213169 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1213119 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1213168 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1213082 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1213083 | — | IC50 | = | 180.0 | nM | 6.75 |