Assay Detail
Binding
CHEMBL1216987
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Inhibition of human HDAC6
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical phylogenetics of histone deacetylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.06 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96051 | SCRIPTAID | — | 1 | 9.60 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 9.00 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.82 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 8.80 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 8.80 |
| CHEMBL1213492 | GIVINOSTAT | 4.0 | 1 | 8.38 |
| CHEMBL353581 | PYROXAMIDE | 1.0 | 1 | 8.32 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 8.02 |
| CHEMBL356066 | DACINOSTAT | 2.0 | 1 | 8.02 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | — | 1 | 7.84 |
| CHEMBL356769 | TUBACIN | — | 1 | 7.80 |
| CHEMBL1213458 | — | — | 1 | 7.52 |
| CHEMBL1213457 | — | — | 1 | 7.50 |
| CHEMBL55895 | PHENYLBUTYRYLHYDROXAMIC ACID | — | 1 | 6.82 |
| CHEMBL1213539 | NILTUBACIN | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96051 | SCRIPTAID | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL99 | TRICHOSTATIN | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL483254 | PANOBINOSTAT | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL408513 | BELINOSTAT | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL98 | VORINOSTAT | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL1213492 | GIVINOSTAT | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL353581 | PYROXAMIDE | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL343448 | ROMIDEPSIN | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL356066 | DACINOSTAT | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL356769 | TUBACIN | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1213458 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL1213457 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL55895 | PHENYLBUTYRYLHYDROXAMIC ACID | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL1213539 | NILTUBACIN | Ki | = | 2200.0 | nM | 5.66 |