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Assay Detail

CHEMBL1216989

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Activity of human HDAC8
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone deacetylase 8 (CHEMBL3192)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Chemical phylogenetics of histone deacetylases.
Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R.
Nat Chem Biol (2010) 6 : 238 -243
PubMed 20139990 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 17 6.79 9.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL343448 ROMIDEPSIN 4.0 1 9.82
CHEMBL408513 BELINOSTAT 4.0 1 7.60
CHEMBL1213492 GIVINOSTAT 4.0 1 7.41
CHEMBL99 TRICHOSTATIN 1.0 1 7.35
CHEMBL430060 APICIDIN 1 7.31
CHEMBL1213457 1 7.30
CHEMBL483254 PANOBINOSTAT 4.0 1 6.98
CHEMBL96051 SCRIPTAID 1 6.98
CHEMBL356769 TUBACIN 1 6.77
CHEMBL356066 DACINOSTAT 2.0 1 6.47
CHEMBL98 VORINOSTAT 4.0 1 6.32
CHEMBL1213458 1 6.22
CHEMBL1213539 NILTUBACIN 1 6.12
CHEMBL320497 SUBEROHYDROXAMIC ACID 1 6.02
CHEMBL353581 PYROXAMIDE 1.0 1 6.00
CHEMBL55895 PHENYLBUTYRYLHYDROXAMIC ACID 1 5.73
CHEMBL279636 1 4.98

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL343448 ROMIDEPSIN Ki = 0.15 nM 9.82
CHEMBL408513 BELINOSTAT Ki = 25.0 nM 7.60
CHEMBL1213492 GIVINOSTAT Ki = 39.0 nM 7.41
CHEMBL99 TRICHOSTATIN Ki = 45.0 nM 7.35
CHEMBL430060 APICIDIN Ki = 49.0 nM 7.31
CHEMBL1213457 Ki = 50.0 nM 7.30
CHEMBL483254 PANOBINOSTAT Ki = 105.0 nM 6.98
CHEMBL96051 SCRIPTAID Ki = 105.0 nM 6.98
CHEMBL356769 TUBACIN Ki = 170.0 nM 6.77
CHEMBL356066 DACINOSTAT Ki = 340.0 nM 6.47
CHEMBL98 VORINOSTAT Ki = 480.0 nM 6.32
CHEMBL1213458 Ki = 600.0 nM 6.22
CHEMBL1213539 NILTUBACIN Ki = 750.0 nM 6.12
CHEMBL320497 SUBEROHYDROXAMIC ACID Ki = 950.0 nM 6.02
CHEMBL353581 PYROXAMIDE Ki = 1000.0 nM 6.00
CHEMBL55895 PHENYLBUTYRYLHYDROXAMIC ACID Ki = 1850.0 nM 5.73
CHEMBL279636 Ki = 10500.0 nM 4.98