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Assay Detail

CHEMBL1216990

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Binding
Inhibition of human HDAC9
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone deacetylase 9 (CHEMBL4145)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Chemical phylogenetics of histone deacetylases.
Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R.
Nat Chem Biol (2010) 6 : 238 -243
PubMed 20139990 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 9 5.73 6.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL408513 BELINOSTAT 4.0 1 6.60
CHEMBL1213492 GIVINOSTAT 4.0 1 6.41
CHEMBL99 TRICHOSTATIN 1.0 1 6.10
CHEMBL343448 ROMIDEPSIN 4.0 1 5.96
CHEMBL1213457 1 5.85
CHEMBL483254 PANOBINOSTAT 4.0 1 5.50
CHEMBL96051 SCRIPTAID 1 5.10
CHEMBL356066 DACINOSTAT 2.0 1 5.05
CHEMBL1213458 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL408513 BELINOSTAT Ki = 250.0 nM 6.60
CHEMBL1213492 GIVINOSTAT Ki = 390.0 nM 6.41
CHEMBL99 TRICHOSTATIN Ki = 800.0 nM 6.10
CHEMBL343448 ROMIDEPSIN Ki = 1100.0 nM 5.96
CHEMBL1213457 Ki = 1400.0 nM 5.85
CHEMBL483254 PANOBINOSTAT Ki = 3200.0 nM 5.50
CHEMBL96051 SCRIPTAID Ki = 8000.0 nM 5.10
CHEMBL356066 DACINOSTAT Ki = 9000.0 nM 5.05
CHEMBL1213458 Ki = 10000.0 nM 5.00