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Assay Detail

CHEMBL1217067

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Functional
Antimalarial activity against chloroquine-resistant Plasmodium falciparum
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Quinolines and structurally related heterocycles as antimalarials.
Kaur K, Jain M, Reddy RP, Jain R.
Eur J Med Chem (2010) 45 : 3245 -3264
PubMed 20466465 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.31 7.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL219967 1 7.89
CHEMBL375375 1 7.89
CHEMBL219009 1 7.89
CHEMBL218854 1 7.89
CHEMBL1214317 1 7.68
CHEMBL1214318 1 7.68
CHEMBL1214319 1 7.68
CHEMBL1214373 1 7.68
CHEMBL303933 PIPERAQUINE 3.0 1 7.39
CHEMBL182857 1 7.14
CHEMBL236696 1 5.99
CHEMBL1214611 1 4.94
CHEMBL1213688 1 -
CHEMBL76 CHLOROQUINE 4.0 1 -
CHEMBL1214247 1 -
CHEMBL330383 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL219967 IC50 = 13.0 nM 7.89
CHEMBL375375 IC50 = 13.0 nM 7.89
CHEMBL219009 IC50 = 13.0 nM 7.89
CHEMBL218854 IC50 = 13.0 nM 7.89
CHEMBL1214317 IC50 = 21.0 nM 7.68
CHEMBL1214318 IC50 = 21.0 nM 7.68
CHEMBL1214319 IC50 = 21.0 nM 7.68
CHEMBL1214373 IC50 = 21.0 nM 7.68
CHEMBL303933 PIPERAQUINE IC50 = 41.0 nM 7.39
CHEMBL182857 IC50 = 73.0 nM 7.14
CHEMBL236696 IC50 = 1020.0 nM 5.99
CHEMBL1214611 IC50 = 11400.0 nM 4.94
CHEMBL1213688 IC50 = 0.04 ug.mL-1 -
CHEMBL76 CHLOROQUINE IC50 = 0.113 ug.mL-1 -
CHEMBL1214247 IC50 = 0.0097 ug.mL-1 -
CHEMBL330383 IC50 = 0.039 ug.mL-1 -