Assay Detail
Functional
CHEMBL1217124
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Antiproliferative activity against human BxPC3 cells after 72 hrs by Alamar blue assay
11
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BXPC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.54 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1213890 | — | — | 3 | 6.22 |
| CHEMBL394880 | DIMETHYLENASTRON | — | 1 | 6.13 |
| CHEMBL240690 | — | — | 1 | 5.68 |
| CHEMBL1213888 | — | — | 1 | 5.67 |
| CHEMBL1213889 | — | — | 1 | 5.55 |
| CHEMBL1213953 | — | — | 3 | 5.44 |
| CHEMBL236789 | MONASTROL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1213890 | — | EC50 | = | 601.0 | nM | 6.22 |
| CHEMBL394880 | DIMETHYLENASTRON | EC50 | = | 743.0 | nM | 6.13 |
| CHEMBL1213890 | — | EC50 | = | 736.0 | nM | 6.13 |
| CHEMBL240690 | — | EC50 | = | 2072.0 | nM | 5.68 |
| CHEMBL1213888 | — | EC50 | = | 2158.0 | nM | 5.67 |
| CHEMBL1213889 | — | EC50 | = | 2838.0 | nM | 5.55 |
| CHEMBL1213953 | — | EC50 | = | 3597.0 | nM | 5.44 |
| CHEMBL1213953 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1213953 | — | EC50 | = | 14421.0 | nM | 4.84 |
| CHEMBL1213890 | — | EC50 | = | 33651.0 | nM | 4.47 |
| CHEMBL236789 | MONASTROL | EC50 | > | 100.0 | nM | - |