Assay Detail
Functional
CHEMBL1217359
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Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.88 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.40 |
| CHEMBL1214365 | 3-KETOADOCIAQUINONE A | — | 1 | 5.78 |
| CHEMBL1214422 | 3-KETOADOCIAQUINONE B | — | 1 | 5.38 |
| CHEMBL1214486 | ORHALQUINONE | — | 1 | 4.96 |
| CHEMBL513747 | HELENAQUINONE | — | 1 | - |
| CHEMBL1214423 | TETRAHYDROHALENAQUINONE A | — | 1 | - |
| CHEMBL478749 | XESTOSAPROL A | — | 1 | - |
| CHEMBL455880 | HALENAQUINOL SULFATE SODIUM | — | 1 | - |
| CHEMBL1214424 | XESTOSAPROL C METHYLACETAL | — | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1214365 | 3-KETOADOCIAQUINONE A | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL1214422 | 3-KETOADOCIAQUINONE B | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL1214486 | ORHALQUINONE | IC50 | = | 10940.0 | nM | 4.96 |
| CHEMBL513747 | HELENAQUINONE | IC50 | > | 30000.0 | nM | - |
| CHEMBL1214423 | TETRAHYDROHALENAQUINONE A | IC50 | > | 29000.0 | nM | - |
| CHEMBL478749 | XESTOSAPROL A | IC50 | > | 29000.0 | nM | - |
| CHEMBL455880 | HALENAQUINOL SULFATE SODIUM | IC50 | > | 24000.0 | nM | - |
| CHEMBL1214424 | XESTOSAPROL C METHYLACETAL | IC50 | > | 21000.0 | nM | - |
| CHEMBL53463 | DOXORUBICIN | IC50 | - | — | - |