Assay Detail
Binding
CHEMBL1217616
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]substance P frome human NK1 receptor
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.71 | 9.74 |
| IC50 | 6 | 9.21 | 10.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1214024 | — | — | 2 | 10.91 |
| CHEMBL507340 | — | — | 2 | 10.90 |
| CHEMBL1214025 | — | — | 2 | 9.74 |
| CHEMBL22870 | L-732138 | — | 2 | 9.14 |
| CHEMBL1214027 | — | — | 2 | 8.72 |
| CHEMBL1214026 | — | — | 2 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1214024 | — | IC50 | = | 0.0123 | nM | 10.91 |
| CHEMBL507340 | — | IC50 | = | 0.01259 | nM | 10.90 |
| CHEMBL1214025 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL1214025 | — | IC50 | = | 0.4169 | nM | 9.38 |
| CHEMBL22870 | L-732138 | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL22870 | L-732138 | IC50 | = | 1.479 | nM | 8.83 |
| CHEMBL1214027 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL1214027 | — | IC50 | = | 4.266 | nM | 8.37 |
| CHEMBL1214026 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL1214026 | — | IC50 | = | 134.9 | nM | 6.87 |
| CHEMBL1214024 | — | Ki | = | 0.0053 | nM | - |
| CHEMBL507340 | — | Ki | = | 0.0065 | nM | - |