Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1219187

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to Electrophorus electricus AChE peripheral anionic site
2
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Electrophorus electricus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL4078)
Type SINGLE PROTEIN
Organism Electrophorus electricus

Publication

Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles.
Samadi A, Marco-Contelles J, Soriano E, Alvarez-Pérez M, Chioua M, Romero A, González-Lafuente L, Gandía L, Roda JM, López MG, Villarroya M, García AG, Ríos Cde L.
Bioorg Med Chem (2010) 18 : 5861 -5872
PubMed 20656495 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 5.06 5.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL345124 PROPIDIUM 2 5.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL345124 PROPIDIUM Ki = 8600.0 nM 5.07
CHEMBL345124 PROPIDIUM Ki = 8900.0 nM 5.05