Assay Detail
Binding
CHEMBL1219281
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human RAD51 assessed as dissociation of protein/single-stranded poly-(d-epsilonA) complex formation by fluorescence polarimetry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DNA repair protein RAD51 homolog 1 (CHEMBL2034807) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein: modeling and experimental validation of a chimera peptide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.37 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1215819 | — | — | 1 | 5.82 |
| CHEMBL1215817 | — | — | 1 | 5.60 |
| CHEMBL1215818 | — | — | 1 | 5.30 |
| CHEMBL1215815 | — | — | 1 | 5.16 |
| CHEMBL1215813 | — | — | 1 | 4.96 |
| CHEMBL1215816 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1215819 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1215817 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1215818 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1215815 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1215813 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1215816 | — | IC50 | > | 40000.0 | nM | - |