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Assay Detail

CHEMBL1219535

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 after 72 hrs by LDH assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica.
Chianese G, Yerbanga SR, Lucantoni L, Habluetzel A, Basilico N, Taramelli D, Fattorusso E, Taglialatela-Scafati O.
J Nat Prod (2010) 73 : 1448 -1452
PubMed 20669933 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.59 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL76 CHLOROQUINE 4.0 1 7.52
CHEMBL1215753 AZADIRONE 1 5.79
CHEMBL465226 GEDUNIN 1 5.78
CHEMBL1214757 NEEMFRUITIN A 1 5.55
CHEMBL1214684 EPOXYAZADIRADIONE 1 5.48
CHEMBL1214755 DESMETHYLLIMOCIN B 1 5.32
CHEMBL1075701 PROTOXYLOCARPIN G 1 5.30
CHEMBL465423 DEACETYLGEDUNIN 1 5.29
CHEMBL1214756 SPICATIN 1 5.27
CHEMBL1215754 AZADIRADIONE 1 5.22
CHEMBL1214758 NEEMFRUITIN B 1 5.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL76 CHLOROQUINE IC50 = 30.0 nM 7.52
CHEMBL1215753 AZADIRONE IC50 = 1630.0 nM 5.79
CHEMBL465226 GEDUNIN IC50 = 1660.0 nM 5.78
CHEMBL1214757 NEEMFRUITIN A IC50 = 2820.0 nM 5.55
CHEMBL1214684 EPOXYAZADIRADIONE IC50 = 3300.0 nM 5.48
CHEMBL1214755 DESMETHYLLIMOCIN B IC50 = 4800.0 nM 5.32
CHEMBL1075701 PROTOXYLOCARPIN G IC50 = 5000.0 nM 5.30
CHEMBL465423 DEACETYLGEDUNIN IC50 = 5140.0 nM 5.29
CHEMBL1214756 SPICATIN IC50 = 5400.0 nM 5.27
CHEMBL1215754 AZADIRADIONE IC50 = 5960.0 nM 5.22
CHEMBL1214758 NEEMFRUITIN B IC50 = 9490.0 nM 5.02