Assay Detail
Binding
CHEMBL1219905
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Inhibition of MDR1 expressed in MDCK cells assessed as calcein AM accumulation by fluorescence assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | MDCK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 35 | 4.96 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308033 | — | — | 1 | 5.82 |
| CHEMBL1215647 | — | — | 1 | 5.67 |
| CHEMBL1097450 | — | — | 1 | 5.65 |
| CHEMBL1097451 | — | — | 1 | 5.65 |
| CHEMBL299112 | — | — | 1 | 5.52 |
| CHEMBL1215646 | — | — | 1 | 5.48 |
| CHEMBL1215644 | — | — | 1 | 5.47 |
| CHEMBL1215645 | — | — | 1 | 5.34 |
| CHEMBL1215576 | — | — | 1 | 5.13 |
| CHEMBL507014 | — | — | 1 | 5.00 |
| CHEMBL363325 | — | — | 1 | 4.92 |
| CHEMBL1215713 | — | — | 1 | 4.69 |
| CHEMBL113641 | — | — | 1 | 4.55 |
| CHEMBL1215715 | — | — | 1 | 4.49 |
| CHEMBL486633 | — | — | 1 | 4.34 |
| CHEMBL1215714 | — | — | 1 | 4.30 |
| CHEMBL1215574 | — | — | 1 | 4.30 |
| CHEMBL1215575 | — | — | 1 | 4.28 |
| CHEMBL1215507 | — | — | 1 | 4.28 |
| CHEMBL1215577 | — | — | 1 | 4.26 |
| CHEMBL1215506 | — | — | 1 | - |
| CHEMBL1215437 | — | — | 1 | - |
| CHEMBL574360 | — | — | 1 | - |
| CHEMBL459673 | — | — | 1 | - |
| CHEMBL507873 | — | — | 1 | - |
| CHEMBL456685 | — | — | 1 | - |
| CHEMBL1215438 | — | — | 1 | - |
| CHEMBL459640 | — | — | 1 | - |
| CHEMBL500868 | — | — | 1 | - |
| CHEMBL1215508 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308033 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1215647 | — | EC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL1097450 | — | EC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL1097451 | — | EC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL299112 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1215646 | — | EC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL1215644 | — | EC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL1215645 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1215576 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL507014 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL363325 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1215713 | — | EC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL113641 | — | EC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL1215715 | — | EC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL486633 | — | EC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL1215714 | — | EC50 | = | 49700.0 | nM | 4.30 |
| CHEMBL1215574 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1215575 | — | EC50 | = | 52600.0 | nM | 4.28 |
| CHEMBL1215507 | — | EC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL1215577 | — | EC50 | = | 55400.0 | nM | 4.26 |
| CHEMBL1215509 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL336467 | FUROXAN | EC50 | > | 100000.0 | nM | - |
| CHEMBL1212966 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL320995 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL500095 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1215508 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL500868 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL459640 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1215438 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL456685 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL507873 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL459673 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL574360 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1215437 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1215506 | — | EC50 | > | 100000.0 | nM | - |