Assay Detail
Binding
CHEMBL1220334
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Binding affinity to HCV 2AP54-labelled IRES subdomain 2a RNA in presence of 1 mM Mg2+ by FRET assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Internal ribosome entry site (IRES) (CHEMBL612412) ↗| Type | NUCLEIC-ACID |
| Organism | Hepacivirus hominis |
Publication
Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.14 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223720 | — | — | 1 | 6.22 |
| CHEMBL1213337 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223720 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1213337 | — | EC50 | = | 90000.0 | nM | 4.05 |