Assay Detail

CHEMBL1220372

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Functional

Antiplasmodial activity against pyrimethamine-resistant Plasmodium falciparum HB3 after 72 hrs by SYBR green assay

ChEMBL ↗

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Target

Plasmodium falciparum (CHEMBL364) ↗

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Plasmodium falciparum (CHEMBL364) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Plasmodium falciparum

CHEMBL364

Anchored from Assay target.

Protein identity Plasmodium falciparum

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Plasmodium falciparum
Confidence	1 — Organism
Curated By	Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗

Type	ORGANISM
Organism	Plasmodium falciparum

Publication

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.

Kato N, Sakata T, Breton G, Le Roch KG, Nagle A, Andersen C, Bursulaya B, Henson K, Johnson J, Kumar KA, Marr F, Mason D, McNamara C, Plouffe D, Ramachandran V, Spooner M, Tuntland T, Zhou Y, Peters EC, Chatterjee A, Schultz PG, Ward GE, Gray N, Harper J, Winzeler EA.
Nat Chem Biol (2008) 4 : 347 -356
PubMed 18454143 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.75	6.75

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1213510	PURFALCAMINE	—	1	6.75

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1213510	PURFALCAMINE	EC50	=	178.0	nM	6.75