Assay Detail
Binding
CHEMBL1220784
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.41 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL398567 | — | — | 1 | 8.02 |
| CHEMBL492572 | — | — | 1 | 7.34 |
| CHEMBL1213069 | — | — | 1 | 7.34 |
| CHEMBL1213097 | — | — | 1 | 7.26 |
| CHEMBL1213144 | — | — | 1 | 7.23 |
| CHEMBL1213066 | — | — | 1 | 7.10 |
| CHEMBL492797 | — | — | 1 | 7.09 |
| CHEMBL398568 | — | — | 1 | 7.00 |
| CHEMBL245621 | HALOPEMIDE | 2.0 | 1 | 6.66 |
| CHEMBL1213068 | — | — | 1 | 6.58 |
| CHEMBL1213099 | — | — | 1 | 6.52 |
| CHEMBL1213143 | — | — | 1 | 6.50 |
| CHEMBL1213141 | — | — | 1 | 6.44 |
| CHEMBL1213190 | — | — | 1 | 6.40 |
| CHEMBL1213067 | — | — | 1 | 6.32 |
| CHEMBL1213142 | — | — | 1 | 6.27 |
| CHEMBL524008 | — | — | 1 | 6.18 |
| CHEMBL1213140 | — | — | 1 | 6.11 |
| CHEMBL1213191 | — | — | 1 | 5.92 |
| CHEMBL1213100 | — | — | 1 | 5.85 |
| CHEMBL1213193 | — | — | 1 | 5.50 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 5.37 |
| CHEMBL511475 | — | — | 1 | 5.29 |
| CHEMBL1213192 | — | — | 1 | 5.13 |
| CHEMBL1213098 | — | — | 1 | 4.82 |
| CHEMBL1213274 | — | — | 1 | - |
| CHEMBL1213275 | — | — | 1 | - |
| CHEMBL1213325 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL398567 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL492572 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1213069 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1213097 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1213144 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1213066 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL492797 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL398568 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL245621 | HALOPEMIDE | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1213068 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1213099 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1213143 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL1213141 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1213190 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1213067 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1213142 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL524008 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL1213140 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL1213191 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1213100 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1213193 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL511475 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1213192 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1213098 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1213274 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1213275 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1213325 | — | IC50 | - | — | - |