Assay Detail
Binding
CHEMBL1221024
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Inhibition of wild type Bacteroides thetaiotaomicron beta-mannosidase 2A expressed in Escherichia coli assessed as inhibition of 4-methyllumbelliferone release by spectrophotometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteroides thetaiotaomicron |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural and biochemical evidence for a boat-like transition state in beta-mannosidases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.00 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1213398 | — | — | 1 | 7.32 |
| CHEMBL1213399 | — | — | 1 | 7.14 |
| CHEMBL1213400 | — | — | 1 | 6.29 |
| CHEMBL1213397 | MANNOIMIDAZOLE | — | 1 | 5.77 |
| CHEMBL1213402 | — | — | 1 | 5.76 |
| CHEMBL1213444 | — | — | 1 | 5.23 |
| CHEMBL1213440 | — | — | 1 | 4.48 |
| CHEMBL1213442 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1213398 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL1213399 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL1213400 | — | Ki | = | 514.0 | nM | 6.29 |
| CHEMBL1213397 | MANNOIMIDAZOLE | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL1213402 | — | Ki | = | 1752.0 | nM | 5.76 |
| CHEMBL1213444 | — | Ki | = | 5836.0 | nM | 5.23 |
| CHEMBL1213440 | — | Ki | = | 33230.0 | nM | 4.48 |
| CHEMBL1213442 | — | Ki | = | 197100.0 | nM | - |