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Assay Detail

CHEMBL1225353

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human CD69 receptor expressed in Escherichia coli by equilibrium dialysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Early activation antigen CD69 (CHEMBL3308911)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthetic N-acetyl-D-glucosamine based fully branched tetrasaccharide, a mimetic of the endogenous ligand for CD69, activates CD69+ killer lymphocytes upon dimerization via a hydrophilic flexible linker.
Kovalová A, Ledvina M, Saman D, Zyka D, Kubícková M, Zídek L, Sklenár V, Pompach P, Kavan D, Bílý J, Vanek O, Kubínková Z, Libigerová M, Ivanová L, Antolíková M, Mrázek H, Rozbeský D, Hofbauerová K, Kren V, Bezouska K.
J Med Chem (2010) 53 : 4050 -4065
PubMed 20433142 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 8.49 8.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1222111 1 8.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1222111 Kd = 3.2 nM 8.49