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Assay Detail

CHEMBL1225449

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of indoleamine-2,3-dioxygenase
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Indoleamine 2,3-dioxygenase 1 (CHEMBL4685)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase.
Matsuno K, Takai K, Isaka Y, Unno Y, Sato M, Takikawa O, Asai A.
Bioorg Med Chem Lett (2010) 20 : 5126 -5129
PubMed 20688518 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 42 5.26 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1224626 1 7.00
CHEMBL1224483 1 6.40
CHEMBL1224556 1 5.92
CHEMBL1224314 1 5.89
CHEMBL1224559 1 5.89
CHEMBL1224560 1 5.85
CHEMBL1224557 BENZENEMETHANETHIOL 1 5.77
CHEMBL1224558 1 5.75
CHEMBL332901 1 5.72
CHEMBL1224312 1 5.66
CHEMBL1224393 1 5.58
CHEMBL1224555 1 5.50
CHEMBL1224561 1 5.46
CHEMBL1224311 1 5.34
CHEMBL1224310 1 5.00
CHEMBL1224396 1 4.96
CHEMBL1224313 1 4.89
CHEMBL1224390 1 4.80
CHEMBL1224484 1 4.77
CHEMBL1224395 1 4.72
CHEMBL1224488 1 4.68
CHEMBL1224315 1 4.52
CHEMBL1224394 1 4.28
CHEMBL1224487 1 4.24
CHEMBL1224309 1 4.21
CHEMBL1224552 1 4.00
CHEMBL1224486 1 -
CHEMBL1224628 1 -
CHEMBL1237213 1 -
CHEMBL1224482 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1224626 IC50 = 100.0 nM 7.00
CHEMBL1224483 IC50 = 400.0 nM 6.40
CHEMBL1224556 IC50 = 1200.0 nM 5.92
CHEMBL1224314 IC50 = 1300.0 nM 5.89
CHEMBL1224559 IC50 = 1300.0 nM 5.89
CHEMBL1224560 IC50 = 1400.0 nM 5.85
CHEMBL1224557 BENZENEMETHANETHIOL IC50 = 1700.0 nM 5.77
CHEMBL1224558 IC50 = 1800.0 nM 5.75
CHEMBL332901 IC50 = 1900.0 nM 5.72
CHEMBL1224312 IC50 = 2200.0 nM 5.66
CHEMBL1224393 IC50 = 2600.0 nM 5.58
CHEMBL1224555 IC50 = 3200.0 nM 5.50
CHEMBL1224561 IC50 = 3500.0 nM 5.46
CHEMBL1224311 IC50 = 4600.0 nM 5.34
CHEMBL1224310 IC50 = 10000.0 nM 5.00
CHEMBL1224396 IC50 = 11000.0 nM 4.96
CHEMBL1224313 IC50 = 13000.0 nM 4.89
CHEMBL1224390 IC50 = 16000.0 nM 4.80
CHEMBL1224484 IC50 = 17000.0 nM 4.77
CHEMBL1224395 IC50 = 19000.0 nM 4.72
CHEMBL1224488 IC50 = 21000.0 nM 4.68
CHEMBL1224315 IC50 = 30000.0 nM 4.52
CHEMBL1224394 IC50 = 52000.0 nM 4.28
CHEMBL1224487 IC50 = 57000.0 nM 4.24
CHEMBL1224309 IC50 = 61000.0 nM 4.21
CHEMBL1224552 IC50 = 100000.0 nM 4.00
CHEMBL1088499 IC50 > 100000.0 nM -
CHEMBL1224553 IC50 > 100000.0 nM -
CHEMBL13218 IC50 > 100000.0 nM -
CHEMBL477764 IC50 > 100000.0 nM -
CHEMBL1224554 IC50 > 100000.0 nM -
CHEMBL538001 IC50 > 100000.0 nM -
CHEMBL1224398 IC50 > 100000.0 nM -
CHEMBL1224489 IC50 > 100000.0 nM -
CHEMBL1224392 IC50 > 100000.0 nM -
CHEMBL1224397 IC50 > 100000.0 nM -
CHEMBL1224485 IC50 > 100000.0 nM -
CHEMBL1224391 IC50 > 100000.0 nM -
CHEMBL1224482 IC50 > 100000.0 nM -
CHEMBL1237213 IC50 > 100000.0 nM -
CHEMBL1224628 IC50 > 100000.0 nM -
CHEMBL1224486 IC50 > 100000.0 nM -