Assay Detail
Binding
CHEMBL1225823
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Inhibition of HIV1 integrase strand transfer activity after 1 hr
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis of polyhydroxylated aromatics having amidation of piperazine nitrogen as HIV-1 integrase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.91 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19977 | — | — | 1 | 6.11 |
| CHEMBL1224051 | — | — | 1 | 4.89 |
| CHEMBL1224124 | — | — | 1 | 4.81 |
| CHEMBL1224052 | — | — | 1 | 4.76 |
| CHEMBL1224122 | — | — | 1 | 4.71 |
| CHEMBL1224053 | — | — | 1 | 4.60 |
| CHEMBL1224123 | — | — | 1 | 4.50 |
| CHEMBL1223934 | — | — | 1 | - |
| CHEMBL1223935 | — | — | 1 | - |
| CHEMBL1223936 | — | — | 1 | - |
| CHEMBL1223937 | — | — | 1 | - |
| CHEMBL1224050 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19977 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL1224051 | — | IC50 | = | 12830.0 | nM | 4.89 |
| CHEMBL1224124 | — | IC50 | = | 15410.0 | nM | 4.81 |
| CHEMBL1224052 | — | IC50 | = | 17470.0 | nM | 4.76 |
| CHEMBL1224122 | — | IC50 | = | 19270.0 | nM | 4.71 |
| CHEMBL1224053 | — | IC50 | = | 24940.0 | nM | 4.60 |
| CHEMBL1224123 | — | IC50 | = | 31310.0 | nM | 4.50 |
| CHEMBL1223934 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1223935 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1223936 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1223937 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1224050 | — | IC50 | > | 100000.0 | nM | - |