Assay Detail
Binding
CHEMBL1225825
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Nav 1.7 channel by electrophysiology
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 9 subunit alpha (CHEMBL4296) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substituted biaryl pyrazoles as sodium channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.10 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1224266 | — | — | 1 | 10.74 |
| CHEMBL1224265 | — | — | 1 | 9.96 |
| CHEMBL1224198 | — | — | 1 | 7.89 |
| CHEMBL1224197 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1224266 | — | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL1224265 | — | Ki | = | 0.111 | nM | 9.96 |
| CHEMBL1224198 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1224197 | — | Ki | = | 15.0 | nM | 7.82 |