Assay Detail
Functional
CHEMBL1226009
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Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.03 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1223738 | 27-DEOXYLYNGBYABELLIN A | — | 1 | 7.92 |
| CHEMBL453207 | LYNGBYABELLIN A | — | 1 | 7.33 |
| CHEMBL1223739 | LYNGBYABELLIN J | — | 1 | 7.27 |
| CHEMBL508049 | LYNGBYABELLIN B | — | 1 | 5.96 |
| CHEMBL1223736 | — | — | 1 | 4.89 |
| CHEMBL1223734 | LYNGBYALOSIDE | — | 1 | 4.43 |
| CHEMBL1223735 | — | — | 1 | 4.42 |
| CHEMBL1223737 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1223738 | 27-DEOXYLYNGBYABELLIN A | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL453207 | LYNGBYABELLIN A | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1223739 | LYNGBYABELLIN J | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL508049 | LYNGBYABELLIN B | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1223736 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1223734 | LYNGBYALOSIDE | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL1223735 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL1223737 | — | IC50 | > | 100000.0 | nM | - |