Assay Detail
Functional
CHEMBL1226258
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at iGluR6 L439C mutant expressed in human HEK293 cells assessed as increase in intracellular Ca2+ levels by FURA-2-M staining based fluorimetric method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate 2 (CHEMBL3683) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Allosteric control of an ionotropic glutamate receptor with an optical switch.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 4.75 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62057 | — | — | 1 | 4.75 |
| CHEMBL1222147 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62057 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1222147 | — | EC50 | = | 180000.0 | nM | - |