Assay Detail
Binding
CHEMBL1226599
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human KSP A133D mutant using varying ATP levels in presence of saturating levels of microtubule by Lineweaver-Burke plot
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.51 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1222153 | — | — | 1 | 8.85 |
| CHEMBL243668 | — | — | 1 | 8.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1222153 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL243668 | — | Ki | = | 6.8 | nM | 8.17 |