Assay Detail
Functional
CHEMBL1227064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with fused GAL4-LBD assessed as transactivation after 12 hrs by luciferase reporter gene assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | BGC-823 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 4immunitygroup A member 1 (CHEMBL1293229) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cytosporone B is an agonist for nuclear orphan receptor Nur77.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 9.94 | 9.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1221517 | CYTOSPORONE B | — | 1 | 9.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1221517 | CYTOSPORONE B | EC50 | = | 0.115 | nM | 9.94 |