Assay Detail
Binding
CHEMBL1227291
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli K-12 recombinant His-tagged folylpoly-gamma-glutamate synthetase expressed in Escherichia coli BL21 LC-MS/MS method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli K-12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydrofolate synthase/folylpolyglutamate synthase (CHEMBL3309008) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli (strain K12) |
Publication
A domino effect in antifolate drug action in Escherichia coli.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 5.51 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46294 | DIHYDROFOLIC ACID | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46294 | DIHYDROFOLIC ACID | Ki | = | 3100.0 | nM | 5.51 |