Assay Detail
Binding
CHEMBL1227415
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Inhibition of LFA1-mediated Staphylococcal enterotoxin B-stimulated human T cell activation in presence of 10% fetal bovine serum
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.26 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1222290 | — | — | 1 | 7.16 |
| CHEMBL1222021 | — | — | 1 | 6.62 |
| CHEMBL1222288 | — | — | 1 | 6.58 |
| CHEMBL1222022 | — | — | 1 | 6.37 |
| CHEMBL1222132 | — | — | 1 | 6.26 |
| CHEMBL1222289 | — | — | 1 | 6.19 |
| CHEMBL1221969 | — | — | 1 | 5.92 |
| CHEMBL1221972 | — | — | 1 | 5.80 |
| CHEMBL1222133 | — | — | 1 | 5.42 |
| CHEMBL1222291 | — | — | 1 | - |
| CHEMBL1221919 | — | — | 1 | - |
| CHEMBL1221970 | — | — | 1 | - |
| CHEMBL1221971 | — | — | 1 | - |
| CHEMBL1222229 | — | — | 1 | - |
| CHEMBL1222228 | — | — | 1 | - |
| CHEMBL1222227 | — | — | 1 | - |
| CHEMBL1222226 | — | — | 1 | - |
| CHEMBL1222131 | — | — | 1 | - |
| CHEMBL1222024 | — | — | 1 | - |
| CHEMBL1222023 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1222290 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1222021 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1222288 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1222022 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1222132 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1222289 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1221969 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1221972 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1222133 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1222291 | — | IC50 | - | — | - | |
| CHEMBL1221919 | — | IC50 | - | — | - | |
| CHEMBL1221970 | — | IC50 | - | — | - | |
| CHEMBL1221971 | — | IC50 | - | — | - | |
| CHEMBL1222229 | — | IC50 | - | — | - | |
| CHEMBL1222228 | — | IC50 | - | — | - | |
| CHEMBL1222227 | — | IC50 | - | — | - | |
| CHEMBL1222226 | — | IC50 | - | — | - | |
| CHEMBL1222131 | — | IC50 | - | — | - | |
| CHEMBL1222024 | — | IC50 | - | — | - | |
| CHEMBL1222023 | — | IC50 | - | — | - |