Assay Detail
Binding
CHEMBL1227437
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Inhibition of HIV 1 recombinant integrase
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Development of 2-pyrrolidinyl-N-methyl pyrimidones as potent and orally bioavailable HIV integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.79 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1223541 | — | — | 1 | 8.05 |
| CHEMBL1223401 | — | — | 1 | 8.00 |
| CHEMBL1223471 | — | — | 1 | 8.00 |
| CHEMBL1223470 | — | — | 1 | 8.00 |
| CHEMBL1223542 | — | — | 1 | 8.00 |
| CHEMBL1223469 | — | — | 1 | 7.82 |
| CHEMBL1223472 | — | — | 1 | 7.82 |
| CHEMBL1222461 | — | — | 1 | 7.72 |
| CHEMBL1223400 | — | — | 1 | 7.70 |
| CHEMBL1222460 | — | — | 1 | 7.70 |
| CHEMBL1223543 | — | — | 1 | 7.68 |
| CHEMBL388908 | — | — | 1 | 7.64 |
| CHEMBL1223544 | — | — | 1 | 7.62 |
| CHEMBL1222458 | — | — | 1 | 7.57 |
| CHEMBL1222459 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1223541 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1223401 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1223471 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1223470 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1223542 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1223469 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1223472 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1222461 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1223400 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1222460 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1223543 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL388908 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1223544 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1222458 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1222459 | — | IC50 | = | 32.0 | nM | 7.50 |