Assay Detail
Binding
CHEMBL1227578
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Inhibition of Escherichia coli DNA gyraseB assessed as inhibition of pBR322 supercoiling by densitometry
23
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.56 | 7.30 |
| Ki | 11 | 6.57 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1222354 | — | — | 2 | 10.30 |
| CHEMBL9 | NORFLOXACIN | 4.0 | 2 | 10.05 |
| CHEMBL50 | QUERCETIN | 3.0 | 2 | 9.74 |
| CHEMBL36506 | NOVOBIOCIN | 4.0 | 1 | 7.30 |
| CHEMBL1222360 | — | — | 2 | 6.72 |
| CHEMBL1222355 | — | — | 2 | 6.68 |
| CHEMBL1222356 | — | — | 2 | 6.55 |
| CHEMBL1222352 | — | — | 2 | 6.47 |
| CHEMBL1222359 | — | — | 2 | 6.34 |
| CHEMBL1222353 | — | — | 2 | 5.96 |
| CHEMBL1222357 | — | — | 2 | 5.92 |
| CHEMBL1222358 | — | — | 2 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1222354 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL9 | NORFLOXACIN | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL50 | QUERCETIN | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL36506 | NOVOBIOCIN | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL9 | NORFLOXACIN | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1222354 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL50 | QUERCETIN | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1222360 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1222355 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1222356 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1222352 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1222359 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1222353 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1222357 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL1222358 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL1222355 | — | Ki | = | 1480.0 | nM | 5.83 |
| CHEMBL1222360 | — | Ki | = | 1930.0 | nM | 5.71 |
| CHEMBL1222356 | — | Ki | = | 2640.0 | nM | 5.58 |
| CHEMBL1222359 | — | Ki | = | 2770.0 | nM | 5.56 |
| CHEMBL1222352 | — | Ki | = | 2870.0 | nM | 5.54 |
| CHEMBL1222353 | — | Ki | = | 6610.0 | nM | 5.18 |
| CHEMBL1222357 | — | Ki | = | 40080.0 | nM | 4.40 |
| CHEMBL1222358 | — | Ki | = | 46960.0 | nM | 4.33 |