Assay Detail
Functional
CHEMBL1227768
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Agonist activity at RXRalpha by luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.56 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1221641 | — | — | 1 | 8.28 |
| CHEMBL1023 | BEXAROTENE | 4.0 | 1 | 7.70 |
| CHEMBL1221640 | — | — | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1221641 | — | EC50 | = | 5.28 | nM | 8.28 |
| CHEMBL1023 | BEXAROTENE | EC50 | = | 19.8 | nM | 7.70 |
| CHEMBL1221640 | — | EC50 | = | 205.0 | nM | 6.69 |