Assay Detail
Functional
CHEMBL1228384
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Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 3,3-diindolyl oxyindoles efficiently catalysed by FeCl3 and their in vitro evaluation for anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.68 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1223016 | — | — | 1 | 5.12 |
| CHEMBL1223090 | — | — | 1 | 5.04 |
| CHEMBL1223018 | — | — | 1 | 4.92 |
| CHEMBL1223088 | — | — | 1 | 4.89 |
| CHEMBL1222878 | — | — | 1 | 4.85 |
| CHEMBL1222954 | — | — | 1 | 4.63 |
| CHEMBL1223019 | — | — | 1 | 4.61 |
| CHEMBL550004 | — | — | 1 | 4.47 |
| CHEMBL1222879 | — | — | 1 | 4.34 |
| CHEMBL551943 | — | — | 1 | 4.33 |
| CHEMBL557057 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1223016 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1223090 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1223018 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1223088 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL1222878 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL1222954 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL1223019 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL550004 | — | IC50 | = | 33600.0 | nM | 4.47 |
| CHEMBL1222879 | — | IC50 | = | 45400.0 | nM | 4.34 |
| CHEMBL551943 | — | IC50 | = | 46800.0 | nM | 4.33 |
| CHEMBL557057 | — | IC50 | = | 49800.0 | nM | 4.30 |