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Assay Detail

CHEMBL1228385

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis of 3,3-diindolyl oxyindoles efficiently catalysed by FeCl3 and their in vitro evaluation for anticancer activity.
Kamal A, Srikanth YV, Khan MN, Shaik TB, Ashraf M.
Bioorg Med Chem Lett (2010) 20 : 5229 -5231
PubMed 20673629 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.80 5.18

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1222954 1 5.18
CHEMBL1222878 1 5.05
CHEMBL1222879 1 4.92
CHEMBL564411 1 4.92
CHEMBL1223088 1 4.89
CHEMBL1223090 1 4.89
CHEMBL1222880 1 4.84
CHEMBL551943 1 4.80
CHEMBL1223018 1 4.80
CHEMBL1223019 1 4.78
CHEMBL1223016 1 4.75
CHEMBL557057 1 4.69
CHEMBL1222953 1 4.63
CHEMBL1223089 1 4.62
CHEMBL550004 1 4.52
CHEMBL1223017 1 4.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1222954 IC50 = 6600.0 nM 5.18
CHEMBL1222878 IC50 = 9000.0 nM 5.05
CHEMBL1222879 IC50 = 12000.0 nM 4.92
CHEMBL564411 IC50 = 12000.0 nM 4.92
CHEMBL1223088 IC50 = 12800.0 nM 4.89
CHEMBL1223090 IC50 = 13000.0 nM 4.89
CHEMBL1222880 IC50 = 14600.0 nM 4.84
CHEMBL551943 IC50 = 15800.0 nM 4.80
CHEMBL1223018 IC50 = 16000.0 nM 4.80
CHEMBL1223019 IC50 = 16600.0 nM 4.78
CHEMBL1223016 IC50 = 18000.0 nM 4.75
CHEMBL557057 IC50 = 20400.0 nM 4.69
CHEMBL1222953 IC50 = 23400.0 nM 4.63
CHEMBL1223089 IC50 = 23800.0 nM 4.62
CHEMBL550004 IC50 = 30200.0 nM 4.52
CHEMBL1223017 IC50 = 36600.0 nM 4.44