Assay Detail
Functional
CHEMBL1228529
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Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxic potential of heterocyclic cyclohexanone analogues of curcumin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 5.65 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1224773 | — | — | 1 | 6.52 |
| CHEMBL100326 | — | — | 1 | 6.10 |
| CHEMBL1224755 | — | — | 1 | 5.96 |
| CHEMBL1224782 | — | — | 1 | 5.96 |
| CHEMBL1224781 | — | — | 1 | 5.96 |
| CHEMBL1224757 | — | — | 1 | 5.82 |
| CHEMBL1224765 | — | — | 1 | 5.72 |
| CHEMBL1224771 | — | — | 1 | 5.68 |
| CHEMBL17205 | CYCLOVALONE | 2.0 | 1 | 5.58 |
| CHEMBL1224759 | — | — | 1 | 5.50 |
| CHEMBL1224758 | — | — | 1 | 5.48 |
| CHEMBL1224780 | — | — | 1 | 5.42 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.12 |
| CHEMBL1224790 | — | — | 1 | 5.07 |
| CHEMBL1224783 | — | — | 1 | 4.89 |
| CHEMBL1224766 | — | — | 1 | - |
| CHEMBL387599 | — | — | 1 | - |
| CHEMBL562131 | — | — | 1 | - |
| CHEMBL1224760 | — | — | 1 | - |
| CHEMBL518575 | — | — | 1 | - |
| CHEMBL98369 | — | — | 1 | - |
| CHEMBL1224772 | — | — | 1 | - |
| CHEMBL476632 | TENYLIDONE | 2.0 | 1 | - |
| CHEMBL1224784 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1224773 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL100326 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1224755 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1224782 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1224781 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1224757 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1224765 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1224771 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL17205 | CYCLOVALONE | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1224759 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1224758 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1224780 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL140 | CURCUMIN | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL1224790 | — | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL1224783 | — | EC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL1224766 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL387599 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL562131 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1224760 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL518575 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL98369 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL1224772 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL476632 | TENYLIDONE | EC50 | > | 30000.0 | nM | - |
| CHEMBL1224784 | — | EC50 | > | 30000.0 | nM | - |