Assay Detail
Binding
CHEMBL1228530
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Inhibition of NF-kappaB activation in human K562 cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxic potential of heterocyclic cyclohexanone analogues of curcumin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.32 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1224771 | — | — | 1 | 6.10 |
| CHEMBL1224773 | — | — | 1 | 6.05 |
| CHEMBL100326 | — | — | 1 | 6.00 |
| CHEMBL1224782 | — | — | 1 | 5.82 |
| CHEMBL1224758 | — | — | 1 | 5.66 |
| CHEMBL1224755 | — | — | 1 | 5.60 |
| CHEMBL1224757 | — | — | 1 | 5.60 |
| CHEMBL1224759 | — | — | 1 | 5.42 |
| CHEMBL1224780 | — | — | 1 | 5.40 |
| CHEMBL1224783 | — | — | 1 | 5.40 |
| CHEMBL1224781 | — | — | 1 | 5.20 |
| CHEMBL17205 | CYCLOVALONE | 2.0 | 1 | 5.00 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.82 |
| CHEMBL1224790 | — | — | 1 | 4.47 |
| CHEMBL1224772 | — | — | 1 | 4.33 |
| CHEMBL1224765 | — | — | 1 | 4.32 |
| CHEMBL1224760 | — | — | 1 | - |
| CHEMBL387599 | — | — | 1 | - |
| CHEMBL476632 | TENYLIDONE | 2.0 | 1 | - |
| CHEMBL518575 | — | — | 1 | - |
| CHEMBL1224766 | — | — | 1 | - |
| CHEMBL562131 | — | — | 1 | - |
| CHEMBL98369 | — | — | 1 | - |
| CHEMBL1224784 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1224771 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1224773 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL100326 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1224782 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1224758 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1224755 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1224757 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1224759 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1224780 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1224783 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1224781 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL17205 | CYCLOVALONE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL140 | CURCUMIN | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1224790 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1224772 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL1224765 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL1224760 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL387599 | — | IC50 | - | — | - | |
| CHEMBL476632 | TENYLIDONE | IC50 | > | 200000.0 | nM | - |
| CHEMBL518575 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1224766 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL562131 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL98369 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL1224784 | — | IC50 | > | 200000.0 | nM | - |