Assay Detail
Functional
CHEMBL1228532
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Cytotoxicity against human SKBR3 cells after 72 hrs by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxic potential of heterocyclic cyclohexanone analogues of curcumin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.18 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1224755 | — | — | 1 | 6.70 |
| CHEMBL1224773 | — | — | 1 | 6.40 |
| CHEMBL100326 | — | — | 1 | 6.22 |
| CHEMBL1224782 | — | — | 1 | 6.16 |
| CHEMBL1224781 | — | — | 1 | 5.96 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1224755 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1224773 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL100326 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1224782 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1224781 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL140 | CURCUMIN | IC50 | = | 2400.0 | nM | 5.62 |