Assay Detail
Binding
CHEMBL1228686
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Binding affinity to cathepsin B in crude rat liver homogenates using [125I]DCG-04 based competition protein labeling by SDS-PAGE method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Activity-based probes that target diverse cysteine protease families.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.92 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1221752 | — | — | 1 | 8.14 |
| CHEMBL1221749 | — | — | 1 | 7.82 |
| CHEMBL1221748 | — | — | 1 | 6.92 |
| CHEMBL1221751 | — | — | 1 | 6.66 |
| CHEMBL1221750 | — | — | 1 | 6.04 |
| CHEMBL1221693 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1221752 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL1221749 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1221748 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1221751 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1221750 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL1221693 | — | IC50 | = | 1200.0 | nM | 5.92 |