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Assay Detail

CHEMBL1243603

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Binding
Inhibition of KDR
ChEMBL ↗
71
Total Activities
71
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3D QSAR studies on a series of potent and high selective inhibitors for three kinases of RTK family.
Cao H, Zhang H, Zheng X, Gao D.
J Mol Graph Model (2007) 26 : 236 -245
PubMed 17293140 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 71 6.99 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL196363 — — 1 8.52
CHEMBL382979 — — 1 8.52
CHEMBL194911 — — 1 8.52
CHEMBL371329 — — 1 8.22
CHEMBL425749 — — 1 7.96
CHEMBL371206 — — 1 7.92
CHEMBL370545 — — 1 7.89
CHEMBL198297 — — 1 7.82
CHEMBL197635 — — 1 7.77
CHEMBL371510 — — 1 7.72
CHEMBL197353 — — 1 7.72
CHEMBL366241 — — 1 7.58
CHEMBL371225 — — 1 7.58
CHEMBL372744 — — 1 7.47
CHEMBL371379 — — 1 7.47
CHEMBL371889 — — 1 7.46
CHEMBL382517 — — 1 7.46
CHEMBL197592 — — 1 7.44
CHEMBL196841 — — 1 7.44
CHEMBL195955 — — 1 7.34
CHEMBL381207 — — 1 7.34
CHEMBL197828 — — 1 7.30
CHEMBL370325 — — 1 7.28
CHEMBL198267 — — 1 7.28
CHEMBL369908 — — 1 7.28
CHEMBL196499 — — 1 7.28
CHEMBL196020 — — 1 7.26
CHEMBL196747 — — 1 7.26
CHEMBL193752 — — 1 7.24
CHEMBL199031 — — 1 7.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL196363 — IC50 = 3.02 nM 8.52
CHEMBL382979 — IC50 = 3.02 nM 8.52
CHEMBL194911 — IC50 = 3.02 nM 8.52
CHEMBL371329 — IC50 = 6.026 nM 8.22
CHEMBL425749 — IC50 = 10.96 nM 7.96
CHEMBL371206 — IC50 = 12.02 nM 7.92
CHEMBL370545 — IC50 = 12.88 nM 7.89
CHEMBL198297 — IC50 = 15.14 nM 7.82
CHEMBL197635 — IC50 = 16.98 nM 7.77
CHEMBL371510 — IC50 = 19.05 nM 7.72
CHEMBL197353 — IC50 = 19.05 nM 7.72
CHEMBL371225 — IC50 = 26.3 nM 7.58
CHEMBL366241 — IC50 = 26.3 nM 7.58
CHEMBL372744 — IC50 = 33.88 nM 7.47
CHEMBL371379 — IC50 = 33.88 nM 7.47
CHEMBL371889 — IC50 = 34.67 nM 7.46
CHEMBL382517 — IC50 = 34.67 nM 7.46
CHEMBL197592 — IC50 = 36.31 nM 7.44
CHEMBL196841 — IC50 = 36.31 nM 7.44
CHEMBL195955 — IC50 = 45.71 nM 7.34
CHEMBL381207 — IC50 = 45.71 nM 7.34
CHEMBL197828 — IC50 = 50.12 nM 7.30
CHEMBL196499 — IC50 = 52.48 nM 7.28
CHEMBL369908 — IC50 = 52.48 nM 7.28
CHEMBL370325 — IC50 = 52.48 nM 7.28
CHEMBL198267 — IC50 = 52.48 nM 7.28
CHEMBL196020 — IC50 = 54.95 nM 7.26
CHEMBL196747 — IC50 = 54.95 nM 7.26
CHEMBL193752 — IC50 = 57.54 nM 7.24
CHEMBL199031 — IC50 = 61.66 nM 7.21
CHEMBL194149 — IC50 = 61.66 nM 7.21
CHEMBL198155 — IC50 = 64.57 nM 7.19
CHEMBL194150 — IC50 = 64.57 nM 7.19
CHEMBL365784 — IC50 = 69.18 nM 7.16
CHEMBL196615 — IC50 = 83.18 nM 7.08
CHEMBL372174 — IC50 = 95.5 nM 7.02
CHEMBL371332 — IC50 = 100.0 nM 7.00
CHEMBL194366 — IC50 = 100.0 nM 7.00
CHEMBL194270 — IC50 = 109.65 nM 6.96
CHEMBL445394 — IC50 = 109.65 nM 6.96
CHEMBL194236 — IC50 = 120.23 nM 6.92
CHEMBL371890 — IC50 = 128.82 nM 6.89
CHEMBL1242373 — IC50 = 151.36 nM 6.82
CHEMBL381034 — IC50 = 158.49 nM 6.80
CHEMBL195964 — IC50 = 169.82 nM 6.77
CHEMBL372960 — IC50 = 169.82 nM 6.77
CHEMBL363393 — IC50 = 181.97 nM 6.74
CHEMBL363389 — IC50 = 181.97 nM 6.74
CHEMBL425387 — IC50 = 181.97 nM 6.74
CHEMBL195567 — IC50 = 186.21 nM 6.73