Assay Detail

CHEMBL1243675

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Functional

Antiproliferative activity in human HeLa cells after 3 days by MTT assay

ChEMBL ↗

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Target

HeLa (CHEMBL399) ↗

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Primary target HeLa

CHEMBL399

Anchored from Assay target.

Protein identity HeLa

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HeLa
Confidence	1 — Organism
Curated By	Autocuration

Target

HeLa (CHEMBL399) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

Kotake Y, Sagane K, Owa T, Mimori-Kiyosue Y, Shimizu H, Uesugi M, Ishihama Y, Iwata M, Mizui Y.
Nat Chem Biol (2007) 3 : 570 -575
PubMed 17643112 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.25	8.25

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1242745	PLADIENOLIDE B	—	1	8.25

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1242745	PLADIENOLIDE B	IC50	=	5.6	nM	8.25