Assay Detail
Functional
CHEMBL1243939
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Antiangiogenic activity against HUVEC after 24 hrs by calcein AM staining-based fluorescent microscopy
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.32 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1081312 | — | — | 1 | 9.51 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 9.23 |
| CHEMBL573339 | PI-103 | — | 1 | 9.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1081312 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL573339 | PI-103 | IC50 | = | 0.6 | nM | 9.22 |