Assay Detail
Binding
CHEMBL1243968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant PI3Kgamma by radioactive phosphotransfer assay in presence of 10 uM ATP
209
Total Activities
209
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 209 | 5.81 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1241944 | — | — | 1 | 7.55 |
| CHEMBL1241299 | — | — | 1 | 7.41 |
| CHEMBL1233882 | — | — | 1 | 7.37 |
| CHEMBL1241768 | — | — | 1 | 7.37 |
| CHEMBL1242287 | — | — | 1 | 7.36 |
| CHEMBL1242376 | — | — | 1 | 7.27 |
| CHEMBL1241678 | — | — | 1 | 7.24 |
| CHEMBL1242119 | — | — | 1 | 7.22 |
| CHEMBL1233881 | — | — | 1 | 7.14 |
| CHEMBL1240544 | — | — | 1 | 7.10 |
| CHEMBL1240553 | — | — | 1 | 7.06 |
| CHEMBL1241776 | — | — | 1 | 7.05 |
| CHEMBL1242475 | — | — | 1 | 7.05 |
| CHEMBL1241774 | — | — | 1 | 7.02 |
| CHEMBL1242476 | — | — | 1 | 7.00 |
| CHEMBL1241578 | — | — | 1 | 7.00 |
| CHEMBL1242202 | — | — | 1 | 6.95 |
| CHEMBL1242386 | — | — | 1 | 6.95 |
| CHEMBL1240554 | — | — | 1 | 6.94 |
| CHEMBL1242028 | — | — | 1 | 6.93 |
| CHEMBL1242201 | — | — | 1 | 6.92 |
| CHEMBL1242294 | — | — | 1 | 6.91 |
| CHEMBL1241484 | — | — | 1 | 6.85 |
| CHEMBL1242666 | — | — | 1 | 6.85 |
| CHEMBL1241676 | — | — | 1 | 6.83 |
| CHEMBL1242208 | — | — | 1 | 6.78 |
| CHEMBL1241683 | — | — | 1 | 6.74 |
| CHEMBL1241945 | — | — | 1 | 6.73 |
| CHEMBL1242112 | — | — | 1 | 6.72 |
| CHEMBL1241767 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1241944 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1241299 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1233882 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1241768 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1242287 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1242376 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1241678 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1242119 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1233881 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1240544 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1240553 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1241776 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL1242475 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1241774 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1242476 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL1241578 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1242202 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1242386 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1240554 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL1242028 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL1242201 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1242294 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL1242666 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1241484 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1241676 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL1242208 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL1241683 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL1241945 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL1242112 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1242290 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1241301 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1241767 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1242377 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL1242756 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1242209 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL1241491 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL1241949 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL1242568 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL1242285 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1241581 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL1242656 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL1241580 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL1242569 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL1242477 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1242198 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1242114 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1242749 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL1241490 | — | IC50 | = | 347.0 | nM | 6.46 |
| CHEMBL1242659 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL1242113 | — | IC50 | = | 355.0 | nM | 6.45 |