Assay Detail
Binding
CHEMBL1243973
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Inhibition of recombinant HCK by radioactive phosphotransfer assay in presence of 10 uM ATP
210
Total Activities
209
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 210 | 6.60 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1241676 | — | — | 1 | 9.74 |
| CHEMBL1241484 | — | — | 1 | 8.70 |
| CHEMBL1241581 | — | — | 1 | 8.70 |
| CHEMBL1241578 | — | — | 1 | 8.40 |
| CHEMBL1242199 | — | — | 1 | 8.36 |
| CHEMBL1242568 | — | — | 1 | 8.35 |
| CHEMBL1242664 | — | — | 1 | 8.30 |
| CHEMBL1242026 | — | — | 1 | 8.29 |
| CHEMBL1242295 | — | — | 1 | 8.27 |
| CHEMBL1242656 | — | — | 1 | 8.24 |
| CHEMBL1241580 | — | — | 1 | 8.24 |
| CHEMBL1081312 | — | — | 1 | 8.10 |
| CHEMBL1241768 | — | — | 1 | 8.10 |
| CHEMBL1241678 | — | — | 1 | 8.06 |
| CHEMBL1242852 | — | — | 1 | 8.05 |
| CHEMBL1242287 | — | — | 1 | 8.05 |
| CHEMBL1242377 | — | — | 1 | 8.04 |
| CHEMBL1242285 | — | — | 1 | 8.00 |
| CHEMBL1242202 | — | — | 1 | 8.00 |
| CHEMBL1242293 | — | — | 1 | 8.00 |
| CHEMBL1242566 | — | — | 1 | 7.96 |
| CHEMBL1242376 | — | — | 1 | 7.92 |
| CHEMBL1241487 | — | — | 1 | 7.89 |
| CHEMBL1242294 | — | — | 1 | 7.82 |
| CHEMBL1242114 | — | — | 1 | 7.75 |
| CHEMBL1242201 | — | — | 1 | 7.75 |
| CHEMBL1242574 | — | — | 1 | 7.75 |
| CHEMBL1242109 | — | — | 1 | 7.72 |
| CHEMBL1241677 | — | — | 1 | 7.70 |
| CHEMBL1242662 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1241676 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL1241581 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1241484 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1241578 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1242199 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL1242568 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL1242664 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1242026 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL1242295 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1242656 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL1241580 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL1241768 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1081312 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1241678 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL1242287 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL1242852 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1242377 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL1242285 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1242202 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1242293 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1242566 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1242376 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1241487 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1242294 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1242574 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1242201 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1242114 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1242109 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1241677 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1242662 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1242748 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1230790 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1242024 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1241299 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1242657 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1241945 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1242111 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1242477 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1242750 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1241579 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1242475 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1242286 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1242476 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1241485 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1241483 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1242572 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1242567 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1242848 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1242198 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1241241 | — | IC50 | = | 47.0 | nM | 7.33 |