Assay Detail
Binding
CHEMBL1243976
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Inhibition of recombinant VEGFR2 by radioactive phosphotransfer assay in presence of 10 uM ATP
209
Total Activities
209
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 209 | 5.65 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1241676 | — | — | 1 | 8.37 |
| CHEMBL1242295 | — | — | 1 | 8.05 |
| CHEMBL1242026 | — | — | 1 | 8.00 |
| CHEMBL1242662 | — | — | 1 | 8.00 |
| CHEMBL1081312 | — | — | 1 | 7.92 |
| CHEMBL1242293 | — | — | 1 | 7.72 |
| CHEMBL1241484 | — | — | 1 | 7.70 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.57 |
| CHEMBL1242287 | — | — | 1 | 7.40 |
| CHEMBL1242109 | — | — | 1 | 7.37 |
| CHEMBL1242285 | — | — | 1 | 7.36 |
| CHEMBL1242199 | — | — | 1 | 7.32 |
| CHEMBL1242376 | — | — | 1 | 7.26 |
| CHEMBL1241578 | — | — | 1 | 7.26 |
| CHEMBL1242202 | — | — | 1 | 7.26 |
| CHEMBL1241580 | — | — | 1 | 7.21 |
| CHEMBL1241678 | — | — | 1 | 7.18 |
| CHEMBL1242377 | — | — | 1 | 7.17 |
| CHEMBL1242294 | — | — | 1 | 7.12 |
| CHEMBL1242656 | — | — | 1 | 7.11 |
| CHEMBL1242198 | — | — | 1 | 7.03 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.02 |
| CHEMBL1241768 | — | — | 1 | 6.99 |
| CHEMBL1242568 | — | — | 1 | 6.97 |
| CHEMBL1242289 | — | — | 1 | 6.96 |
| CHEMBL1242114 | — | — | 1 | 6.92 |
| CHEMBL1242664 | — | — | 1 | 6.87 |
| CHEMBL1241271 | — | — | 1 | 6.82 |
| CHEMBL1242852 | — | — | 1 | 6.82 |
| CHEMBL1241677 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1241676 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1242295 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1242026 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1242662 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1081312 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1242293 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1241484 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1242287 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1242109 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1242285 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1242199 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1241578 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1242376 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1242202 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1241580 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1241678 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1242377 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1242294 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1242656 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1242198 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL535 | SUNITINIB | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1241768 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL1242568 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL1242289 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL1242114 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL1242664 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL1242852 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL1241271 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL1241677 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL1242385 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL1242750 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL1241486 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL1242573 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL1242024 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL1230790 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL1241270 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL1242201 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL1242113 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL1242386 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL1233882 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1242572 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1242657 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL1242748 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL1242475 | — | IC50 | = | 411.0 | nM | 6.39 |
| CHEMBL1242477 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1241770 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL1242574 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL1242566 | — | IC50 | = | 517.0 | nM | 6.29 |
| CHEMBL1242661 | — | IC50 | = | 550.0 | nM | 6.26 |