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Assay Detail

CHEMBL1244602

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human VEGFR2 after 60 mins
ChEMBL ↗
81
Total Activities
81
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Molecular modeling studies of vascular endothelial growth factor receptor tyrosine kinase inhibitors using QSAR and docking.
Du J, Lei B, Qin J, Liu H, Yao X.
J Mol Graph Model (2009) 27 : 642 -654
PubMed 19081278 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 81 8.48 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL409538 — — 1 9.70
CHEMBL272824 — — 1 9.70
CHEMBL1242387 — — 1 9.70
CHEMBL411630 — — 1 9.70
CHEMBL270092 — — 1 9.52
CHEMBL429585 — — 1 9.52
CHEMBL269916 — — 1 9.52
CHEMBL272691 — — 1 9.52
CHEMBL1241686 — — 1 9.43
CHEMBL270342 — — 1 9.35
CHEMBL429743 — — 1 9.31
CHEMBL411091 — — 1 9.30
CHEMBL271563 — — 1 9.30
CHEMBL1242575 — — 1 9.30
CHEMBL270548 — — 1 9.30
CHEMBL270985 — — 1 9.30
CHEMBL272198 — — 1 9.22
CHEMBL259461 — — 1 9.22
CHEMBL412291 — — 1 9.22
CHEMBL1242478 — — 1 9.22
CHEMBL407715 — — 1 9.15
CHEMBL269915 — — 1 9.10
CHEMBL408478 — — 1 9.10
CHEMBL406388 — — 1 9.10
CHEMBL271984 — — 1 9.05
CHEMBL272875 — — 1 9.00
CHEMBL272878 — — 1 9.00
CHEMBL429430 — — 1 9.00
CHEMBL270058 — — 1 9.00
CHEMBL270057 — — 1 9.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL409538 — IC50 = 0.1995 nM 9.70
CHEMBL272824 — IC50 = 0.1995 nM 9.70
CHEMBL1242387 — IC50 = 0.1995 nM 9.70
CHEMBL411630 — IC50 = 0.1995 nM 9.70
CHEMBL270092 — IC50 = 0.302 nM 9.52
CHEMBL429585 — IC50 = 0.302 nM 9.52
CHEMBL269916 — IC50 = 0.302 nM 9.52
CHEMBL272691 — IC50 = 0.302 nM 9.52
CHEMBL1241686 — IC50 = 0.3715 nM 9.43
CHEMBL270342 — IC50 = 0.4467 nM 9.35
CHEMBL429743 — IC50 = 0.4898 nM 9.31
CHEMBL411091 — IC50 = 0.5012 nM 9.30
CHEMBL271563 — IC50 = 0.5012 nM 9.30
CHEMBL1242575 — IC50 = 0.5012 nM 9.30
CHEMBL270548 — IC50 = 0.5012 nM 9.30
CHEMBL270985 — IC50 = 0.5012 nM 9.30
CHEMBL272198 — IC50 = 0.6026 nM 9.22
CHEMBL259461 — IC50 = 0.6026 nM 9.22
CHEMBL412291 — IC50 = 0.6026 nM 9.22
CHEMBL1242478 — IC50 = 0.6026 nM 9.22
CHEMBL407715 — IC50 = 0.7079 nM 9.15
CHEMBL269915 — IC50 = 0.7943 nM 9.10
CHEMBL408478 — IC50 = 0.7943 nM 9.10
CHEMBL406388 — IC50 = 0.7943 nM 9.10
CHEMBL271984 — IC50 = 0.8913 nM 9.05
CHEMBL272875 — IC50 = 1.0 nM 9.00
CHEMBL410841 — IC50 = 1.0 nM 9.00
CHEMBL273062 — IC50 = 1.0 nM 9.00
CHEMBL270306 — IC50 = 1.0 nM 9.00
CHEMBL269914 — IC50 = 1.0 nM 9.00
CHEMBL270057 — IC50 = 1.0 nM 9.00
CHEMBL270058 — IC50 = 1.0 nM 9.00
CHEMBL429430 — IC50 = 1.0 nM 9.00
CHEMBL272878 — IC50 = 1.0 nM 9.00
CHEMBL270978 — IC50 = 1.0 nM 9.00
CHEMBL1241685 — IC50 = 1.202 nM 8.92
CHEMBL269871 — IC50 = 1.288 nM 8.89
CHEMBL409103 — IC50 = 1.288 nM 8.89
CHEMBL272252 — IC50 = 1.288 nM 8.89
CHEMBL270547 — IC50 = 1.995 nM 8.70
CHEMBL272693 — IC50 = 1.995 nM 8.70
CHEMBL272823 — IC50 = 1.995 nM 8.70
CHEMBL270983 — IC50 = 1.995 nM 8.70
CHEMBL259252 — IC50 = 2.138 nM 8.67
CHEMBL411284 — IC50 = 2.884 nM 8.54
CHEMBL271181 — IC50 = 3.02 nM 8.52
CHEMBL272822 — IC50 = 3.02 nM 8.52
CHEMBL1242667 — IC50 = 3.802 nM 8.42
CHEMBL270754 — IC50 = 3.802 nM 8.42
CHEMBL273064 — IC50 = 3.981 nM 8.40