Assay Detail
Binding
CHEMBL1244633
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Binding affinity to His-tagged Vibrio cholerae recombinant MTAN expressed in Escherichia coli B21
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Vibrio cholerae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (CHEMBL1250374) ↗| Type | SINGLE PROTEIN |
| Organism | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) |
Publication
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 9.26 | 10.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1232180 | — | — | 1 | 10.19 |
| CHEMBL1242854 | — | — | 1 | 10.15 |
| CHEMBL405346 | — | — | 1 | 10.14 |
| CHEMBL1230265 | — | — | 1 | 9.48 |
| CHEMBL1242855 | — | — | 1 | 8.80 |
| CHEMBL1241493 | — | — | 1 | 8.68 |
| CHEMBL1241494 | — | — | 1 | 8.66 |
| CHEMBL1195586 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1232180 | — | Kd | = | 0.064 | nM | 10.19 |
| CHEMBL1242854 | — | Kd | = | 0.07 | nM | 10.15 |
| CHEMBL405346 | — | Kd | = | 0.073 | nM | 10.14 |
| CHEMBL1230265 | — | Kd | = | 0.33 | nM | 9.48 |
| CHEMBL1242855 | — | Kd | = | 1.6 | nM | 8.80 |
| CHEMBL1241493 | — | Kd | = | 2.1 | nM | 8.68 |
| CHEMBL1241494 | — | Kd | = | 2.2 | nM | 8.66 |
| CHEMBL1195586 | — | Kd | = | 10.0 | nM | 8.00 |