Assay Detail
Functional
CHEMBL1244699
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Cytotoxicity against human MV4-11 cells after 72 hrs by cell titer-blue assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.24 | 9.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 9.25 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 9.06 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 8.68 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 8.37 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 7.92 |
| CHEMBL124660 | TANDUTINIB | 2.0 | 1 | 7.22 |
| CHEMBL1240703 | CGP-52421 | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL535 | SUNITINIB | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL124660 | TANDUTINIB | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1240703 | CGP-52421 | IC50 | = | 64.0 | nM | 7.19 |