Assay Detail
Binding
CHEMBL1244848
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Binding affinity to FLT3 ITD mutant
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 8.05 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 9.00 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 8.82 |
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 8.06 |
| CHEMBL124660 | TANDUTINIB | 2.0 | 1 | 8.04 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 7.96 |
| CHEMBL1240703 | CGP-52421 | — | 1 | 7.37 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL535 | SUNITINIB | Kd | = | 0.99 | nM | 9.00 |
| CHEMBL603469 | LESTAURTINIB | Kd | = | 1.5 | nM | 8.82 |
| CHEMBL576982 | QUIZARTINIB | Kd | = | 8.8 | nM | 8.06 |
| CHEMBL124660 | TANDUTINIB | Kd | = | 9.1 | nM | 8.04 |
| CHEMBL608533 | MIDOSTAURIN | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL1240703 | CGP-52421 | Kd | = | 43.0 | nM | 7.37 |
| CHEMBL1336 | SORAFENIB | Kd | = | 79.0 | nM | 7.10 |