Assay Detail
Binding
CHEMBL1245052
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Inhibition of human Chymase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.54 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 7.58 |
| CHEMBL218394 | BOCEPREVIR | 4.0 | 1 | 7.50 |
| CHEMBL4525964 | VANIPREVIR | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231813 | TELAPREVIR | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL218394 | BOCEPREVIR | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4525964 | VANIPREVIR | IC50 | > | 10000.0 | nM | - |